HPV Medical Studies - Symptoms

Falk L, Fredlund H, Jensen JS. Department of Dermatology and Venereology, University Hospital, Orebro, SE -701 85 Orebro, Sweden.

OBJECTIVES: To study the prevalence, symptoms, and signs of Mycoplasma genitalium and Chlamydia trachomatis infections in women attending a Swedish STD clinic, accessible for both sexes, and in a group of young women called in the cervical cancer screening programme. METHODS: A cross sectional study among female STD clinic attendees in Orebro and a study among women called for Papanicolaou smear screening. Attendees were examined for urethritis and cervicitis. First void urine and endocervical samples were tested for M genitalium and C trachomatis. RESULTS: The prevalence of C trachomatis and M genitalium in the STD clinic population was 10% (45/465) and 6% (26/461), respectively. Dual infection was diagnosed in four women. In the cancer screening group of women the corresponding prevalence was 2% (1/59) and 0%, respectively. Among the STD clinic attendees there were no significant differences in symptoms (32% v 23%, RR 1.4, 95% CI 0.6 to 3.4) or signs (71% v 50%, RR 1.4, 95% CI 0.9 to 2.3) between C trachomatis and M genitalium infections. Microscopic signs of cervicitis were significantly more common among M genitalium and C trachomatis infected women than in the cancer screening group of women. 56% (15/27) of male partners of M genitalium infected women were infected with M genitalium compared to 59% of male partners of C trachomatis infected women who were infected with C trachomatis (p = 0.80). CONCLUSIONS: M genitalium is a common infection associated with cervicitis and with a high prevalence of infected sexual partners supporting its role as a cause of sexually transmitted infection.

J Infect Dis. 2005 Mar 15;191(6):924-9. Epub 2005 Feb 8.

Factors associated with absence of H2O2-producing Lactobacillus among women with bacterial vaginosis.

Beigi RH, Wiesenfeld HC, Hillier SL, Straw T, Krohn MA. Department of Obstetrics and Gynecology, MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio 44109, USA.

BACKGROUND: Women with bacterial vaginosis have different microbiological profiles. Our objective was to identify risk factors for an absence of H(2)O(2)-producing lactobacilli among women with bacterial vaginosis. METHODS: We performed a retrospective analysis of 947 women with bacterial vaginosis who were enrolled in prospective studies investigating vaginal colonization and genital-tract infections. RESULTS: Women were categorized into 2 groups: those with H(2)O(2)-producing lactobacilli present (n=191; 20.2%) and those with H(2)O(2)-producing lactobacilli absent (n=756; 79.8%). Multivariate logistic regression demonstrated that douching >/=2 times during the past month (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.1-6.0) and having >/=3 sex partners during the past year (OR, 4.5; 95% CI, 1.8-11.7) were predictive of an absence of H(2)O(2)-producing lactobacilli. CONCLUSION: Among women with bacterial vaginosis, H(2)O(2)-producing lactobacillus colonization is influenced by sexual activity and douching habits. These findings may have important implications for response to treatment, relapse rate, and risk for sexually-transmitted-disease acquisition among women with bacterial vaginosis.

Publication Types:
• Clinical Trial

Akush Ginekol (Sofiia). 2004;43(6):23-6.

Polygynax in the treatment of fungal and non specific vaginitis.

Goran D, Vesna A, Adela S, Biljana TK, Snezana M. Department of Gynecology and Obstetrics, Clinical Centre, Skopje.

BACKGROUND: Polygynax is a product commercialized in the form of vaginal capsule, associating bactericidal antibiotics: Neomycin, Polymyxin B and Nystatin--an antifungal agent which is fungicidal and fungistatic in vitro and in vivo. OBJECTIVE: The objectives of the study were to analyze the clinical and bacteriological efficacy of Polygynax in the treatment of bacterial vaginitis with one or more germs (mixed vaginitis) and Candida infections, and to investigate the correlation between the results of the initial clinical examination and bacteriological studies. MATERIAL AND METHODS: The study covered 88 patients diagnosed with mixed vaginitis during initial screening of vaginal flora (direct Gram stains and standard microbiology laboratory methods for cultivation of vagina/ cervix smears with antibiotic susceptibility testing). The patients were treated with Polygynax, applied in form of vaginal capsules (during 12 days, application before retiring). After at least 30 days following last day of therapy, the same diagnostic swabs were repeated. In this period, averaging 38.4 days, sexual abstinence was recommended. RESULTS: The results showed that total clearance of present germs was found in 83/88 patients (94.3% of the cases), according to the repeated cervico- vaginal smears. CONCLUSION: Polygynax is a treatment of preference against fungal infections, with added advantage of having wide antibacterial spectrum.

Am J Obstet Gynecol. 2004 Dec;191(6):1898-906.

Intravaginal metronidazole gel versus metronidazole plus nystatin ovules for bacterial vaginosis: a randomized controlled trial.

Sanchez S, Garcia PJ, Thomas KK, Catlin M, Holmes KK. Hospital dos de Mayo, Lima, Peru.

OBJECTIVE: We compared metronidazole 0.75% gel (containing 37.5 mg metronidazole per dose) with ovules containing metronidazole 500 mg and nystatin 100,000 U, for intravaginal treatment of bacterial vaginosis (BV). STUDY DESIGN: In a single-blinded trial, symptomatic women with BV by both Amsel and Nugent criteria were randomly assigned to gel or ovules, once nightly for 5 nights, and asked to return 3 times after treatment. Analyses were intent-to-treat. RESULTS: Of 151 women with BV by both criteria at enrollment, 138 (91%) returned at least once. Product limit estimates for persistence or recurrence of BV at 14, 42, and 104 days were 20% (95% CI 10%-29%), 38% (95% CI 25%-48%), and 52% (95% CI 37%-63%) after gel treatment, and 4% (95% CI 0%-9%), 17% (95% CI 7%-26%), and 33% (95% CI 21%-46%) after ovule treatment ( P = .01). Among women without BV at first follow-up, subsequent intercourse without condoms independently predicted subsequent recurrence ( P

Publication Types:
• Clinical Trial
• Randomized Controlled Trial

HPV Medical Studies - HPV and Other Infections Symptoms Links

Genital Canidiasis - Vaginal Yeast Infections - Clear facts about genital canidiasis or vaginal yeast infections. Explores causes, symptoms, diagnosis, treatments, and prevention of genital canidiasis.

Safe sex and STI - Read about symptoms, test and treatment for HPV and HIV.